People are at greater risk of developing cancer as they get older, but have so far yet to be explained why. Now scientists have discovered that a
naturally produced protein that helps protect us from cancer may also be the one to determine how long we will live. The said protein ensures that cells do not divide if they are damaged and also determine lifespan in the nematode worm. The research showed that these 'checkpoint proteins' - thought only to operate in cells that divide - function in cells that no longer divide as well. Looking at checkpoint proteins as a gear, it has been long known that they drive the
cancer engine, but now they are also known to drive the longevity engine. The research involved genetically removing checkpoint proteins from the microscopic worm C. elegans, and the researchers caused a 15-30% increase in the worm's lifespan. The scientists might be able to design strategies where they can keep checkpoint proteins active in dividing cells and stop them working in cells that no longer divide, such as brain cells. This will increase the survival of brain cells or 'neurons' and could provide a new avenue of treatment for neurodegenerative diseases like Alzheimer's.
